Genes that increase the risk of suicide

Four genes have been identified that appear to increase the risk of suicidal thoughts and acts.

The finding has been made in a large-scale study, led by Duke University in the United States and by the Durham office of the US Department of Veterans Affairs (responsible for providing pensions, compensation and other federal benefits to veterans of the establishment military and people who depend on them). Experts from the Bellvitge University Hospital in Hospitalet de Llobregat, Barcelona, ​​as well as the Bellvitge Biomedical Research Institute (IDIBELL), located in Hospitalet de Llobregat and part of the CERCA institution of the Generalitat of Catalonia, have also collaborated in the research. .

The authors of this study ensure that these genes do not predestine the carrier to suffer suicidal thoughts, but they could pose a greater risk, especially when combined with tragic events.

To identify these genetic markers, the entire genome of 633,778 US military veterans has been analyzed. Among them, almost 20% had suffered suicidal thoughts or behavior that had been recorded in their medical records.

The researchers identified four genes with a strong link to suicidal behaviors. First, the estrogen receptor, previously identified as a gene that causes depression and post-traumatic stress disorder. Secondly, the dopamine receptor, related to suicide attempts, schizophrenia or mood disorders, among others. Third, the DCC gene, expressed in brain tissue and which has already been associated with multiple psychiatric disorders. And finally, TRAF3, which is related to antisocial behavior, drug use and Attention Deficit Hyperactivity Disorder (ADHD).

Suicide is a major cause of death. (Illustration: Jorge Munnshe for NCYT from Amazings)

“Although genes represent a small part of the risk compared to other factors, we need to better understand the biological pathways underlying a person’s suicidal behavior,” the researchers say. “Suicide is the fourth leading cause of death among people between the ages of 15 and 29; the more we know, the better we can prevent these tragic deaths.” (Source: IDIBELL)